Search results for "ISM [radio lines]"
showing 10 items of 1018 documents
A theorem of insertion and extension of functions for normal spaces
1993
Parental stress and resilience in autism spectrum disorder and Down syndrome
2020
The aim of this study was to compare parental stress and resilience in parents of children with autism spectrum disorder (ASD), Down syndrome (DS), and typical development (TD), and analyze the relationship between these two constructs. A total of 97 parents participated (ASD: n = 32, DS: n = 23, and TD: n = 42). The instruments used were the Parental Stress Index and the Resilience Scale. The ASD group obtained higher parental stress related to the child’s characteristics but not related to the parents’ characteristics. The three groups obtained moderate resilience, and high resilience was associated with low parental stress in the ASD and DS groups. The higher parental stress obtained in…
Dérivé de la bléomycine générant moins de ROS ? Moins de fibrose ? Une alternative dans le développement d’une thérapie anticancéreuse efficace mais …
2010
Deglycobleomycin (DBLM), the aglycon of the glycopeptide antitumor drug bleomycin (BLM), was first used since 1980 during comparative studies between BLM and DBLM in order to elucidate the role of the sugar component in the mechanism of action of BLM. In fact, the deglycosylation of BLM reduce the toxicity of this molecule and fails to produce reactive oxygen species, responsible for pulmonary fibrosis, and for anti-neoplastic activity of BLM. This causes toxic DNA lesions and ultimately leads to cell death. The therapeutic use of BLM is limited by a dose-dependent lung toxicity that eventually leads to fibrosis. Testing BLM-derivative molecules and defining their molecular mechanisms invol…
Mildronate: An Antiischemic Drug for Neurological Indications
2005
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate is efficient in the treatment of heart ischemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the trea…
DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders.
2021
The DNA-binding activities of compounds used as remedies can display DNA-protection, but also damaging effects in biological systems. The current review compiles literature data on DNA-binding activities of drugs widely used as remedies with different therapeutic indications. The compounds are classified according their mechanism of action: enzyme inhibitors, ion channel inhibitors, inhibitors of viral RNA replication and HIV protease and receptor agonists. DNA binding was reported for such widely used drugs as paracetamol, aspirin, metformin, statins and many others. The capability of the drug to bind DNA is sometimes coupled to genotoxic effects, but in some cases - to genome protection. …
Effects of Antidepressants on Inhibitory Avoidance in Mice: A Review
2012
Neither the biological basis of depression (Nemeroff & Vale, 2005; Kasper & McEwen, 2008) nor the precise mechanism of antidepressant efficacy are completely understood (Dudra-Jastrzebska et al., 2007). Indeed, antidepressants are widely prescribed for anxiety and disorders other than depression. For example, they are the drug therapy of choice for severe anxiety disorders such as agoraphobia, generalized anxiety disorder, social phobia, obsessive-compulsive disorder and post-traumatic stress disorder (Baldessarini, 2001). Antidepressants are also employed as a therapeutic tool in disorders such as drug addition (e.g. Schatzberg, 2000), enuresis (e.g. Humphreys & Reinberg, 2005) and chronic…
E-tourism economics: Editorial for the special issue
2019
Co-citation, bibliographic coupling and leading authors, institutions and countries in the 50 years of Technological Forecasting and Social Change
2021
[EN] Technological Forecasting and Social Change (TF&SC) is a leading international journal that publishes major advances related to technological forecasting and future studies. The journal was launched in 1969 and in 2019 celebrated its 50th anniversary. To celebrate 50 years of outstanding contributions, this study presents a bibliometric analysis of TF&SC publications and patterns of citations within TF&SC in terms of authors, institutions and countries. The analysis relies on the Web of Science Core Collection database for bibliographic content and Visualization of Similarities viewer software for mapping of bibliometric data. Our analysis identifies leading authors, universities and c…
Comparative study of sensory modulation vulnerabilities in children with and without ASD in family and school contexts
2018
Background: Children with autism spectrum disorder (ASD) may present sensory processing alterations that are specific to each environment in which they develop, inevitably impacting their daily fun...